Bruce N. Ames 1996 Publications

351a Taylor, A., Lipman, R. D., Jahngen-Hodge, J., Palmer, V., Smith, D., Padhye, N., Dallal, G. E., Cyr, D. E., Laxman, E., Shepard, D., Morrow, F., Salomon, R., Perrone, G., Asmundsson, G., Meydani, M., Blumberg, J., Mune, M., Harrison, D. E., Archer, J. R. and Shigenaga, M. (1996) Dietary calorie restriction in the Emory mouse: effects on lifespan, eye lens cataract prevalence and progression, levels of ascorbate, glutathione, glucose, and glycohemoglobin, tail collagen breaktime, DNA and RNA oxidation, skin integrity, fecundity, and cancer. Mech. Ageing Dev. 79:33-57. check for PDF

352 Helbock, H. J., Thompson, J., Yeo, H. and Ames, B. N. (1996) N2-Methyl-8-Oxoguanine: A tRNA Urinary Metabolites; Role of Xanthine Oxidase. Free Rad Biol Med 20, 475-481. check for PDF

353 Ames, B. N. and Gold, L. S. (1996) Mutagenesis and Carcinogenesis: Cell Division and DNA Lesions are Key Factors in Mutagenesis, Carcinogenesis and Cancer Prevention. In: Encyclopedia of Cancer, J. R. Bertino, ed. (Academic Press, Orlando, FL), vol. 2, pp. 1120-1128. check for PDF

354 Liu, J., Shigenaga, M. K., Yan, L. and Ames, B. N. (1996) Antioxidant Activity Diethyldithiocarbamate. Free Rad. Res. 24, 461-472. check for PDF

355 Christen, S., Gee, P. and Ames, B. (1996) Mutagenicity of Nitric Oxide in a New Set of Basepair-Specific Salmonella Tester Strains (TA7000 series). Methods Enzymol 269, 267-278. check for PDF

356 Fraga, C. G., Motchnik, P. A., Wyrobek, A. J., Rempel, D. M. and Ames, B. N. (1996) Smoking and Low Antioxidant Levels Increase Oxidative Damage to Sperm DNA. Mutat. Res. 351, 199-203. check for PDF 357 Douki, T., Cadet, J. and Ames, B. N. (1996) An Adduct between Peroxynitrite and 2'-Deoxyguanosine: 4,5-Dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine. Chem. Res.Toxicol. 9, 3-7. check for PDF

358 Beckman, K. B. and Ames, B. N. (1996) Detection and Quantification of Oxidative Adducts of Mitochondrial DNA. Methods Enzymol. 264, 442-453. check for PDF

359 Ames, B. N. (1996) The Causes of Aging and Cancer: The Misinterpretation of Animal Cancer Tests. Human Ecol. Risk Assess. 2, 6-9. check for PDF

360 Park, J-. Y., Shigenaga, M. K. and Ames, B. N. (1996) Induction of Cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or indolo(3,2-b)carbazole Is Associated with Oxidative DNA Damage. Proc. Natl. Acad. Sci. USA 93 (6), 2322-2327. check for PDF

361 Doniger, S., Liu, J., and Ames, B. N. (1996) Adrenalectomy and Oxidative Stress in Rat Brain. Berkeley Scientific 1, 67-70. check for PDF

362 Ames, B. N. and Gold, L. S. (1996) The Causes and Prevention of Cancer: Gaining Perspectives on Management of Risk. In: Improving Risk Management: From Science to Policy, R. W. Hahn, ed. (Oxford University Press), pp. 4-45. check for PDF

363 Liu, J., Shigenaga, M. K., Mori, A. and Ames, B. N. (1996) Free Radicals and Neurodegenerative Diseases: Stress and Oxidative Damage. In: Free Radicals in Brain Physiology and Disorders , L. Packer, M. Hiramatsu, T. Yoshikawa, eds. (Academic Press, San Diego, CA), pp. 403-435 check for PDF

364 Ames, B. N. and Gold, L. S. (1996) The Causes and Prevention of Cancer: An Overview. In: Accomplishments in Cancer Research , J. G. Fortner, P. A. Sharp, eds. (J. B. Lippincott Company, Philadelphia, PA), pp. 70-91. check for PDF

365 Ames, B. N. and Gold, L. S. (1996) Reply to Farber (letter to editor). Cancer Research 56, 4267-4274. check for PDF

366 Ames, B. N. and Gold, L. S. (1996) The Rodent High-dose Cancer Test is Limited at Best: When Cell Division is Ignored, then Risk Assessment will be Flawed. Belle Newsletter 5, 4-7. check for PDF

367 Liu, J., Wang, X., Shigenaga, M. K., Yeo, H. C., Mori, A., and Ames, B. N. (1996) Immobilization Stress Causes Oxidative Damage to Lipid, Protein, and DNA in the Brain of Rats. Faseb J. 10, 1532-1538. check for PDF

368 Ames, B. N., Gold, L. S., and Shigenaga, M. K. (1996) Cancer Prevention, Rodent High-Dose Cancer Tests and Risk Assessment. Risk Anal. 16, 613-617. check for PDF

369 Chen, Q., Marsh, J., Ames, B. N., and Mossman, B. (1996) Detection of 8-oxo-2'-Deoxyguanosine, a Marker of Oxidative DNA Damage, in Culture Medium from Human Mesothelial Cells Exposed to Crocidolite Asbestos. Carcinogenesis 17, 2525-2527. check for PDF

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Contact Information

Mailing Address:
Children's Hospital Oakland Research Institute (CHORI),
5700 Martin Luther King Jr. Way, Oakland CA 94609.
Phone: (510) 450-7625
CHORI E-mail: bames@chori.org

Recent News

November 2008

October 2008

  • A new web graphic of Gold, Ames & Slone uses a Margin of Exposure index to provide a broad perspective on possible cancer hazards from human exposures to chemicals that cause cancer in high dose rodent tests. Exposures include high historical exposures to workers, pharmaceuticals, natural chemicals in the average diet (e.g., natural pesticides that plants produce to defend themselves), air pollutants, food additives, and pesticide residues. Human exposure levels range from close to the rodent carcinogenic dose for a few historical exposures in the workplace to a billion times less the rodent carcinogenic dose for some pesticide residues. Human consumption of the background of natural chemicals in food is usually closer to the rodent carcinogenic dose than pesticide residues or pollutants, and half the natural chemicals tested are carcinogenic in high dose tests. Recent risk assessment methods indicate that for some chemicals the mechanism of carcinogenesis in rodents at high dose is not relevant to humans.

June 2008

  • The CHORI webpage news article on Killilea & Ames magnesium Study:
    read article
  • Ames & Killilea News Study listed in 'AFAR Grantee's In the News' list
    go to AFAR site

April 2008

October 2007

For information on symposium proceedings and media please go to the Second Annual International Bruce Ames Symposium Website held at UC Davis.

Downloadable Media

The downloadable media section is constantly being updated. You will find that some links are not yet available. We apologize for the inconvenience and request that you come back periodically, to check for future availability.

Among the items available for download is a high resolution TIFF formated photograph of Dr. Ames (300 dpi resolution, and a 7MB ZIP archive), and Dr. Ames' streamed video lectures.

Dr. Ames' publications are also available by request to students and colleagues.
To request copies of Dr. Ames' publications, please fill out this electronic form.
Go to media page

Information on Juvenon

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